Prestin Lateral Mobility and Self-Association in Outer Hair Cells
نویسندگان
چکیده
منابع مشابه
Cochlear amplification, outer hair cells and prestin.
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex and probably to the phenomenon of fast adaptation. The extended frequency range of the mammalian cochlea has probably co-evolved with a novel hair cell type, ...
متن کاملPrestin and the dynamic stiffness of cochlear outer hair cells.
The outer hair cell (OHC) lateral wall is a unique trilaminate structure consisting of the plasma membrane, the cortical lattice, and subsurface cisternae. OHCs are capable of altering their length in response to transmembrane voltage change. This so-called electromotile response is presumed to result from conformational changes of membrane-bound protein molecules, named prestin. OHC motility i...
متن کاملExtraction of prestin-dependent and prestin-independent components from complex motile responses in guinea pig outer hair cells.
Electromotility of cochlear outer hair cells (OHC) is associated with conformational changes in the integral membrane protein prestin. We have recently reported that electrical stimulation evokes significant prestin-dependent changes in the length, width, and area of the longitudinal section of OHCs, but not in their volume. In contrast, prestin-independent responses elicited at constant membra...
متن کاملPrestin Regulation and Function in Residual Outer Hair Cells after Noise-Induced Hearing Loss
The outer hair cell (OHC) motor protein prestin is necessary for electromotility, which drives cochlear amplification and produces exquisitely sharp frequency tuning. Tecta(C1509G) transgenic mice have hearing loss, and surprisingly have increased OHC prestin levels. We hypothesized, therefore, that prestin up-regulation may represent a generalized response to compensate for a state of hearing ...
متن کاملPrestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice
A knockin (KI) mouse expressing mutated prestinV499G/Y501H (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs were normal in stiffness and longer than OHCs lacking prestin, accelerated OHC death was unexpectedl...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.4361